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KMID : 0356820080240010064
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Korean Journal of Head & Neck Oncology
2008 Volume.24 No. 1 p.64 ~ p.68
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Papillary Thyroid Carcinoma in Renal Allograft Recipients
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Lee Jan-Dee
Hong Hyeop
Jeong Jong-Ju
Nam Kee-Hyun
Chung Woong-Youn
Soh Euy-Young
Park Cheong-Soo
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Abstract
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Purpose: The chronic use of immunosuppressive therapy in transplant recipients can increase the long-term risk of carcinoma. The aim of this study was to determine the incidence, biological behaviors, and treatment outcomes in PTC(papillary thyroid carcinoma) in renal allograft recipients.
Materials and Methods: The present study examined the incidence and biological behavior of PTCs in RA recipients. A total of 1,739 RA patients treated between January 1986 and December 1999 were followed-up for a median 137(84-238) months. During the follow-up period, 129(7.4%) recipients were identified as having posttransplant malignancies. Of those, 12(0.7%) had PTCs, and these comprised six male and six female patients with a median age of 41(23-57) years.
Results: Nine cases(incidentalomas) were diagnosed based on ultrasonography(US) screening. Eight of those nine were TNM stage I, and two of the three clinical carcinomas were TNM stage IVa. During a median follow-up of 94(18-159) months, two(16.7%) PTC patients developed loco-regional recurrence, but no patients showed distant metastasis. Posttransplant PTC showed no gender bias, and was often associated with aggressive lymphatic metastasis. However, most incidentalomas showed a favorable treatment outcome.
Conclusion: In conclusion, routine surveillance of the thyroid gland using US screening is recommended to ensure early detection, treatment and favorable prognosis in RA patients with PTC.
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KEYWORD
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Posttransplant malignancy, PTC(papillary thyroid carcinoma), Renal allograft
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